Work-related stress may adversely affect physical and psychological health. The aim of this study was to measure biomarkers of stress; cortisol, immunoglobulin A (IgA) and C-reactive protein (CRP) in saliva, among some Egyptian workers and to investigate stress associated work-related and sociodemographic factors. The study included 66 Egyptian workers (50 females and 16 males) with mean age of 38 years. Biomarkers were determined using ELISA technique and a self-reported questionnaire was designed to collect data about variables under study. Results showed significant negative correlation between age and CRP levels. CRP also showed to be significantly higher among the non-married subjects. Salivary biomarkers of stress succeeded to show significant differences among study variables. Researchers showed significantly lower cortisol level than employees group that may suggest acute state of stress.