The effect of ethanolic extract of pulverized mango (Mangifera indica) seed kernel (MSKE) on some hematological parameters in normal and monosodium glutamate (MSG)-intoxicated rats was investigated, using standard protocols. Higher (p< 0.05) red blood cell (RBC) count in MSKE-exposed or in MSG plus high MSKE-exposed rats but non-significantly higher (p>0.05) RBC count in MSG-exposed or in MSG plus low MSKE-exposed group compared to the control. The relative change was highest in the MSKE group compared to rats control (18.36 %) and MSG (14.85 %) rats. The white blood cell (WBC) count in rats in the various treatment groups was higher (p< 0.05) compared to that in the control. However, the WBC count relative to control (55.80 %) and to MSG-treated (16.02 %) groups was (in both cases) highest in the rats concomitantly exposed to MSG and high MSKE. The higher packed cell volume (PCV) value compared to the control and MSG-treated rats was significant (p< 0.05) in the MSKE-treated rats but not statistically significant (p>0.05) in the rats exposed to MSG together with either low or high concentration of MSKE. Thus, MSKE improved, and at highest tested concentration only mitigated MSG-induced influence on, the studied hematological parameters of rats warranting further studies.