Fine particulate matter PM_2.5 has attracted much attention both scientific and public, due to its effects on human health. This study used remotely sensed PM_2.5 to model the the distribution of PM2.5 concentration across the cities of Niger delta region of Nigeria using satellite based measurement. PM_2.5 data that was used for this study was Aerosol Optical Depth (AOD), it was acquired from remotely sensed satellite data from National Aeronautics and Space Administration (NASA's) earth observing system data and information system, PM_2.5concentration data were obtained from 2001 to 2015 and the boundaries for the cities were created and then the annual average PM_2.5 distribution for each city from 2001-2015 were calculated. The calculation showed that PM_2.5 concentration in the Niger delta varied from city to city, and that PM_2.5 is significantly highest in Yenagoa with 23.29 (μg/m3), this confirmed Yenagoa having the highest concentration of PM_2.5, followed by Calabar23.241(μg/m3)and the lowest PM_2.5 concentration was Akure15.299(μg/m3) across the cities of the Niger delta. This means that there is a wide variation in PM_2.5 concentration over the years across the cities. The effect of PM_2.5 concentration is higher inYenagoa, and all the state capitals have annual mean values of PM_2.5 above the WHO guideline value of 10μg/m. PM_2.5 concentration is increasing with years especially as a result of the illegal refining activities, gas and oil pipeline bombing and gas flaring activities, this implies that PM_2.5 concentration will continue to increase as long as these activities continues in the Niger Delta region of Nigeria. This situation can lead to adverse health and environmental health effects on human beings with continuous exposure.