Every geographical region (continent, nation, state and local government) constitutes a system characterized by transport network. The research aims at examining Effects of Commercial Activities on Transportation Route in Urban Centres in Nigeria: A case study of Oba Adesida Road, Akure. It identifies the socio-economic impact of commercial activities on urban transportation system and the usefulness of traffic control to minimize traffic congestion in the study area. The data was collected through observation, questionnaire administration and personal interview survey and secondary source such as photograph and maps adopting simple random sampling with 250 questionnaires. Three (3) sets of questionnaires were used to elicit relevant data for the study. The first set of questionnaires of 100 (9% of the 1,150 stalls) focused on the seller who are stall owners for the assessment of economic impact of commercial activities in the study areas. The second set of 100 questionnaires (0.16% of the 63,340 households of Akure), focused on the buyers who patronize the market place for their daily need to respond to the level of patronage in study areas. The last set of 50 questionnaires (16% of 300 cars that make use of the car park) were directed to drivers who ply the road often to their respective place of work, the car park was the target area for the drivers. However, analysis of the data embraced the usage of statistical package for social science (SPSS). The research revealed that the significant of urban transportation system is not just a factor affected by commercial activities but as a factor that link and relate other factors such as urban growth. It showed that mode of transit and increase in market visitation has resulted into increase in traffic congestion. Conclusively, commercial activities affect the transportation system and invariably has environmental side effects. The problem of traffic and environmental issues should be checked through the eradication of on-street trading, fining the drivers that involved in onstreet parking, they should be mandated to use the parking lot around the area.