Exposure to environmental stressors exert debilitating effects on the health of employees. Workforce in Egypt does not receive -in most cases- suitable preventive measures to face such a problem. Moreover, they lack the awareness of early signs and symptoms of stress. The aim of the present work was to investigate the interrelationship between work stress in terms of physiological and psychological signs and job satisfaction among the Training and capabilities Development Unit (TCD) in National Research Centre of Egypt (NRC). Some personality traits and learning styles were also investigated as predictors of stress. Forty two (12 males and 30 females) employees working at the different departments of TDC were recruited in the study. The sample subjects were asked to complete a survey to estimate their job satisfaction and another for work stress assessment. Participants were asked to fill the Intellectual Style Inventory (ISI) for learning style assessment in addition to some other personality traits. Participants reached 70%. Significant positive association was detected between low job satisfaction and high score on the work stress scale. The judging personality, the front left thinking, the base left perception and the front right thinking styles showed significantly to be the least suffering from signs of stress. Low job satisfaction is associated with work stress prevalence and helps in increasing psychological and physiological signs of distress. The different learning styles as described by the ISI show different responses to work stress and could be beneficial in similar studies.