In this study, relevant literature were empirically reviewed with a view to determining the moderating influence of firm's market orientation on customer relationship management and marketing effectiveness among banks in Port Harcourt. The study is a descriptive study that involved field survey, thus, 105 copies of structured questionnaire were designed to capture information from top executives of the 21 registered money deposit banks in Port Harcourt. We analysed data using spearman's correlation coefficient and regression analysis with the aid of the SPSS version 20.0 software. In conclusion, it was revealed that a firm's market orientation significantly moderates the influence of customer relationship management on marketing effectiveness in the banking sector. Giving the foregone, the study strongly recommended that banks that want to be on the cutting edge should make the customer the primary focus of their business objectives.