This work was done to study the effect of (HF) and (HFF) on level of plasma glucose, insulin, kidney profile, lipid profile and antioxidant status compared to (LF). The statistical analysis of the results showed that total cholesterol, triacylglycerol, plasma glucose, serum insulin, serum NLRP3, kidney nitric oxide and MDA were significantly increased in HFF compared to LF group. But PON1, GSH and HDL-C were significantly decreased in HFF compared to LF group. Our study shows a positive correlation between total cholesterol and triacylglycerol withNLRP3. Also there is a negative correlation between HDL-C, PON1 and GSH withNLRP3. The conclusion that the inflammasome NLRP3 is an important marker that correlate between obesity , type 2 diabetes, oxidative stress and inflammation, So it is recommended to depend on as metabolic syndrome marker.